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Glial Cells

Regulation of Glial Cells

Integrins and Nitric Oxide in the Regulation of Glial Cells: Potential Roles in Pathological Pain

Glial cells form physical connections with neurons and vascular endothelial cells in the brain, thereby constructing the elaborate networks of the tripartite synapse and the neurovascular unit, respectively. In addition to supporting neurons, glial cells modify synaptic plasticity and vascular tone, and in this way play an important role in maintaining brain homeostasis. Upon activation, glial cells produce nitric oxide, a gaseous mediator that diffuses into neighboring cells, wherein it elicits signaling pathways critical for synaptic plasticity and vascular tone. Because nitric oxide is short-lived and can travel only a short distance, glial cells must migrate to and position themselves near the target cells with which glial nitric oxide primarily interacts. Integrins, an essential family of cell adhesion molecules, facilitate effective glial migration and adhesion in the brain during developmental and normal adult stages. Aberrant regulation of nitric oxide and integrins in glial cells is thought to compromise cognitive brain function, and thereby lead to various pathologies. This review focuses on the important pathologic roles that nitric oxide and integrins play in glia and glia-related cells, focusing on their potential involvement in chronic pain syndrome.

Copyright: © 2012 Maruyama K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Barry Bruder

Barry Bruder

CEO & Founder of IASIS Technologies International

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Blog posts are not the opinion of IASIS Technologies International and its providers. No treatment for healing neurological conditions has been expressed or implied.

DISCLAIMER: This website does not contain medical advice. IASIS MCN is not a medical treatment, rather the retraining of the brain and nervous system. The information, including but not limited to text, videos, images and other material contained on this website is for informational purposes only. The purpose of this website is to promote broad consumer understanding and knowledge about IASIS MCN. It is not intended to be a substitute for professional medical advice, diagnosis or treatment. If you believe you have a medical condition, please first, always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read on this website. Video and written success stories contained on this site are the sole experience of those individuals shown or having written them, and are not the opinions of IASIS Technologies, Inc. Never self-medicate or choose to discontinue taking medicine without discussing your medical care with your doctor.

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